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OwnerNed Heindel, Wallace Longton +2inventors
InventorsNed Heindel, Wallace Longton, Christine Martey-Ochola, Robert Rapp
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Novel lactones of polysaccharide carboxylic acids, and methods for the preparation of a variety of conjugates therefrom, as well as the novel conjugates, are provided. Conjugates include metallo-coordinated cisplatin (and carboplatin), as well as conjugates of ellipticinium, aminoglutethimide, mitoxantrone, mitoguazone, cis 3-hexen-1-ol, and other nucleophilic biologically effective agents. Also provided are conjugates via a coupling agent of biologically effective agents, such as Vitamin E, DTPA, TAXOL and TAXOTERE.
A method for synthesizing a pro-compound comprising coupling a reactive polysaccharide carboxylic acid lactone with a bioactive compound, wherein the coupling occurs via ring-opening of the lactone.
A method for synthesizing a therapeutic compound comprising:
A method for synthesizing a conjugated polymer comprising:
A method for synthesizing a therapeutic compound comprising:
A polysaccharide carboxylic acid lactone conjugate, wherein the polysaccharide carboxylic acid lactone is obtained from the group consisting of carboxy- and carboxymethyl cellulose, carboxy- and carboxymethyl cyclodextrin, carboxy- and carboxymethyl starch, carboxy- and carboxymethyl chitosan, and pectin, and wherein the bioactive compound is obtained from the group consisting of cisplatin, carboplatin, aminoglutethimide, ellipticinium, mitoxantrone, mitoguazone, finasteride, alpha-difluoromethylornithine, cis 3-hexen-1-ol, Vitamin E, N,N,N′,N″,N″-diethylenetriaminepentaacetic acid (DPTA), paclitaxel, and docetaxel.
Dependencies are inferred from the claim text.