Truncated baff receptors
AssigneeBiogen Idec MA Inc.
InventorsChristine Ambrose, Jeffrey Thompson, Yen-Ming Hsu, Dingyi Wen, Yaping Sun
Life of this patent
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Abstract
The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.
Claims47
A non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in altered O-linked glycosylation pattern, wherein the BAFF-R glycoprotein retains the ability to bind to BAFF.
A BAFF-R fusion polypeptide comprising:
- (a) a first polypeptide comprising an amino sequence substantially as set out from amino acid 13 to amino acid 43 or amino acids 14 to 43 of SEQ ID NO:1 fused to (b) a second amino acid sequence comprising at least a portion of an immunoglobulin constant region, and optionally (c) a linker joining the first and the second sequences, wherein the BAFF-R fusion polypeptide does not include amino acid 50 to amino acid 56 of SEQ ID NO:1.
A BAFF-R polypeptide comprising amino acids 14 to 56 of SEQ ID NO:1 having mutations at amino acids 50, 51, and 56 of SEQ ID NO:1, wherein amino acids 50 is not serine or threonine, amino acid 51 is not serine or threonine, and amino acid 56 is not serine or threonine.
Dependencies are inferred from the claim text.