Sequences used to identify if a female mammal comprises a mutation in the alpha-fetoprotein sequence(S) or a partial or total deletion of the alpha-fetoprotein sequence(S)

A method to identify if a female mammal subject (including a female human patient) comprises a mutation, partial or total deletion of the alpha-fetoprotein (AFP) DNA sequence in her genome, which comprises the steps of:

• putting into contact a biological sample obtained from the mammal subject, said biological sample comprising the genome of the mammal subject, with sequences that are able to hybridize specifically with the alpha-fetoprotein DNA sequence and/or amplify at least a portion of the alpha-fetoprotein DNA sequence;
• detecting these hybridized sequences or these amplified sequences and detecting if these DNA sequences present a mutation, partial or total deletion.

A method of treatment and/or prevention of a phenotype selected from the group consisting of female sterility, no menstrual cyclization and/or no uteral implantation of an embryo expressed by a female mammal subject (including a female human patient) and which comprises the steps of:

• identifying if a mammal subject present a mutation, partial or total deletion in the alpha-fetoprotein DNA sequence in its genome and may transmit said mutation, partial or total deletion to its descendant(s), (especially to her daughter) that may present said mutation, partial or total deletion homozygously and associated with the said phenotype, and
• treating the mammal by hormone therapy during gestation, in order to allow that the female mammal gives birth to a female mammal which does not present the phenotype associated with the mutation, or the partial or total deletion of the AFP DNA sequence.