Association of snps in the comt locus and neighboring loci with schizophrenia, bipolar disorder, breast cancer and colorectal cancer
OwnerAriel Darvasi, Naomi Zakinventors
Life of this patent
Estimating the term…
Abstract
Methods and kits used for determining predisposition and/or diagnosis of schizophrenia, bipolar disorder, breast cancer and colorectal cancer using genotypes in the COMT locus are disclosed. Also disclosed are methods and drugs for treating these disorders. Further disclosed are methods and kits useful for prediction drug responsiveness towards mental disorders drugs, and more specifically towards schizophrenia drugs.
Claims30
A method of determining a predisposition of a subject to develop schizophrenia, the method comprising determining a presence in a homozygous or heterozygous form, or an absence, of at least one genotype in the COMT locus or in neighboring loci, said neighboring loci are in linkage disequilibrium with said COMT locus, said at least one genotype having been associated with schizophrenia, thereby determining the predisposition of the subject of developing schizophrenia.
A method of determining a predisposition to develop schizophrenia in a female subject, the method comprising determining a presence in a homozygous or heterozygous form, or an absence, of at least one genotype in the COMT locus or in neighboring loci, said neighboring loci are in linkage disequilibrium with said COMT locus, said at least one genotype having been associated with schizophrenia in females in higher association than in males, thereby determining the predisposition of the female subject of developing schizophrenia.
10-48. (canceled)
A kit for determining a predisposition of a subject to develop schizophrenia, the kit comprising a packaging material packaging at least one reagent, said at least one reagent for determining a presence in a homozygous or heterozygous form, or an absence, of at least one genotype in the COMT locus or in neighboring loci, said neighboring loci are in linkage disequilibrium with said COMT locus, said genotype having been associated with schizophrenia, the kit further comprising a notification in or on said packaging material, said notification identifying the kit for use in determining a predisposition of developing schizophrenia.
68-493. (canceled)
Dependencies are inferred from the claim text.