Filtration device and method for removing selected materials from biological fluids

A method for removing at least one selected component from a fluid sample to produce a filtered fluid product, comprising the steps of:

• a) providing a filter, the filter comprising an inlet, an outlet, and a filter assembly, wherein the filter assembly further comprises an outer housing an a plurality of filter surfaces located within the outer housing;
• b) coating the plurality of filter surfaces with an interfacial biomaterial, the interfacial biomaterial comprising a first binding module, configured to selectively bind to the plurality of filter surfaces, and a second binding module, configured to selectively bind to the first binding module and to the at least one selected component;
• c) filtering a fluid sample through the filter assembly such that the blood sample comes into contact with the plurality of filter surfaces and such that the at least one selected component is bound to the second binding molecule of the interfacial biomaterial;
• and
• d) collecting the filtered product at the outlet of the filter.

A method for removing at least two selected components from a fluid sample to produce a filtered fluid product, comprising the steps of:

• a) providing a filter, the filter comprising an inlet, an outlet, and a filter assembly, wherein the filter assembly further comprises an outer housing and a plurality of filter surfaces located within the outer housing;
• b) coating a first portion of the plurality of filter surfaces with a first interfacial biomaterial, the first interfacial biomaterial comprising a first binding module, configured to selectively bind to the first portion of the plurality of filter surfaces, and a second binding module, configured to selectively bind to the first binding module and to a first selected fluid component;
• c) coating a second portion of the plurality of filter surfaces with a second interfacial biomaterial, the first interfacial biomaterial comprising a first binding module, configured to selectively bind to the second portion of the plurality of filter surfaces, and a third binding module, configured to selectively bind to the first binding module and to a second selected fluid component;
• d) filtering a fluid sample through the filter assembly such that the fluid sample comes into contact with the first and second portion of the plurality of filter surfaces and such that first selected fluid component is bound to the second binding module of the first interfacial biomaterial and the second selected fluid component is bound to the third binding module of the second interfacial biomaterial;
• and
• e) collecting the filtered fluid product at the outlet of the filter.