Novel therapies and methods of screening for therapeutic compounds
OwnerCatharina Svanborginventor
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Abstract
A method for killing cells, said method comprising introducing into the nucleus of the cell, a moiety (other than HAMLET) which inhibits histone activity. This method will be useful for example in the treatment of cancer for antibacterial activity. Histones can be used as a basis of screening methods to select therapeutic compounds, and these are also described and claimed.
Claims31
A method for killing cells, said method comprising introducing into the nucleus of the cell, a moiety (other than HAMLET) which interacts with histone in a manner which is interaction is independent of the histone tail and which inhibits histone activity.
A method of screening for moieties which may kill cells, said method comprises contacting a moiety under test with a histone which lacks a histone tail, and detecting an interaction therebetween.
A moiety capable of killing cells, said moiety comprising a histone binding agent, and at least one of a translocation peptide, a nuclear targeting entity, or a cell specific targeting reagent.
Dependencies are inferred from the claim text.