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US 2006/0216766 A1Published application
Assay for protein isoforms
AssigneeAxis-Shield ASA
InventorPhilip Rye
Life of this patent
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Abstract
A method for assaying for a protein having at least two isoforms having different glycosylation patterns, the method including contacting a sample containing the protein with a proteolytic enzyme, and detecting the content or relative content of at least one peptide fragment produced by proteolysis of the protein.
Claims11
A method for assaying for a protein having at least two isoforms having different glycosylation patterns, said method comprising:
- contacting a sample containing said protein with a protein site specific proteolytic enzyme, and detecting the content or relative content of at least one peptide fragment which is produced by proteolysis of one isoform but not by proteolysis of the other isoform(s), through the use of a specific binding partner (sbp) for that fragment or fragments.
Dependencies are inferred from the claim text.