New pharmaceutically-active compounds for the treatment of respiratory diseases
AssigneeBoehringer Ingelheim International GmbH
InventorsIngo Konetzki, Thierry Bouyssou, Philipp Lustenberger, Andreas Schnapp
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Abstract
The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, R2 and R3 may have the meanings specified in the claims and in the description, for preparing a pharmaceutical composition for the treatment of respiratory complaints, as well as new compounds of formula 1, processes for preparing them, and pharmaceutical formulations containing them.
Claims29
A method for treating a respiratory condition selected from the group consisting of obstructive pulmonary diseases, pulmonary emphysema, restrictive pulmonary diseases, interstitial pulmonary diseases, cystic fibrosis, bronchitis, bronchiectasis, ARDS (adult respiratory distress syndrome) and pulmonary oedema, comprising administering to a patient in need thereof a pharmaceutical composition comprising a compound of formula 1:
- wherein
- R1 and R2 are independently hydrogen, halogen or C1-C4-alkyl;
- or R1 and R2 together form a C2-C6-alkylene;
- and
- R3 is hydrogen, halogen, OH, C1-C4-alkyl or —O—C1-C4-alkyl.
A pharmaceutical composition comprising a compound of formula 1:
- wherein
- R1 and R2 are independently ethyl or propyl;
- or R1 and R2 together form —CH2—CH2—, —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2— or —CH2—CH2—CH2—CH2—CH2—;
- and
- R3 is hydrogen, fluorine, chlorine, OH, methyl, ethyl, methoxy or ethoxy.
Dependencies are inferred from the claim text.