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US 2006/0189517 A1Published application
Cross-linked glycopeptide-cephalosporin antibiotics
AssigneeTheravance, Inc.
InventorsPaul Fatheree, Martin Linsell, Daniel Marquess, Sean Trapp, Edmund Moran, James Aggen
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Abstract
This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
Claims13
1-28. (canceled)
A compound of the formula:
- or a pharmaceutically-acceptable salt thereof;
- wherein
- each of X1 and X2 is independently hydrogen or chloro;
- W is N or CCl;
- R1 and R2 are independently selected from hydrogen and C1-6 alkyl;
- each R3 is independently selected from C1-6 alkyl, OR, halo, —SR, —S(O)R, —S(O)2R, and —S(O)2OR, where each R is independently C1-6 alkyl optionally substituted with COOH or 1 to 3 fluoro substituents;
- one of R4 and R5 is hydroxy and the other is hydrogen;
- R6 and R7 are independently hydrogen or methyl;
- R8 is hydrogen or a group of the formula:
- R9 is selected from hydrogen, C1-6 alkyl and C3-6 cycloalkyl, where alkyl and cycloalkyl are optionally substituted with —COOH or 1 to 3 fluoro substituents;
- Rb is hydrogen, methyl or ethyl;
- Rc is C2-12 alkylene, where the alkylene group is optionally substituted with —COOH;
- n is an integer from 0 to 3;
- x is 0 or 1;
- y is 0 or 1;
- and the pyridinium ring is attached to the methylene group at the meta orpara position.
13 more elements
Dependencies are inferred from the claim text.