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US 2006/0188555 A1Published application
Therapeutic peptide formulations with improved stability
OwnerMicheal Cormier, Mahmoud Ameriinventors
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OwnerMicheal Cormier, Mahmoud Ameriinventors
Estimating the term…
Compositions of and methods for formulating and delivering peptide, polypeptide and protein therapeutic agent formulations having enhanced physical stability, and wherein fibril formation is minimized and/or controlled, to yield a consistent and predictable composition viscosity. The compositions of and methods for formulating and delivering peptide, polypeptide and protein therapeutic agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the peptide therapeutic agents.
A composition for coating a transdermal delivery device having stratum corneum-piercing microprojections comprising a formulation of a therapeutically effective amount of a peptide agent and at least one counterion to substantially reduce fibril formation and viscosity variation in the composition.
A method for applying a biocompatible coating to a transdermal delivery device that has at least one stratum cornuem-piercing microprojection comprising the steps of:
A method for transdermally delivering a peptide agent comprising the steps of:
Dependencies are inferred from the claim text.