Transdermal botulinum toxin administration for the treatment of spastic muscle pain
AssigneeAllergan, Inc.
InventorStephen Donovan
Life of this patent
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Abstract
Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bioactivity associated with the neurotoxin. The pharmaceutical compositions are topically applied on a patient, and may be provided in a transdermal patch.
Claims19
1-30. (canceled)
A method of relieving pain in a patient caused by a spastic muscle, the method comprising the steps of:
- (a) applying ultrasound at a frequency between about 10 kHz and 1 MHz to the patient's skin overlying the spastic muscle;
- and
- (b) applying a botulinum toxin to the patient's skin that has received the ultrasound in step (a).
A method of relieving pain in a patient caused by a spastic muscle, the method comprising the steps of:
- (a) applying ultrasound at a frequency between about 10 kHz and 1 MHz to the patient's skin overlying the spastic muscle;
- (b) abrasively removing a portion of a stratum corneum of the patient's skin that received the ultrasound in step (a);
- and
- (b) applying a botulinum toxin type A to the patient's skin that has received the ultrasound in step (a);
- wherein the botulinum toxin type A is applied in a heat activated transdermal patch applied to the patient's skin further comprising an alcohol and a glycerin.
Dependencies are inferred from the claim text.