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OwnerGenichi Kakefuda, Karl-Heinz Ott +2inventors
InventorsGenichi Kakefuda, Karl-Heinz Ott, Jae-Gyu Kwagh, Gerald Stockton
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Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.
1-84. (canceled)
A variant plant acetohydroxy acid synthase (AHAS) protein comprising at least one mutation at an amino acid residue corresponding to amino acid residue M53 of SEQ ID NO:1, wherein the mutation is Met53Thr, wherein said variant plant AHAS protein is more resistant to an herbicide than the wild-type AHAS protein.
Dependencies are inferred from the claim text.