Back to results
US 2006/0154972 A1Published application
Amino acids with affinity for the alpha-2-delta-protein
AssigneePfizer Inc.
InventorsNancy Barta, Jacob Schwarz, Andrew Thorpe, David Wustrow
Life of this patent
Estimating the term…
Abstract
This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
Claims10
(canceled)
A compound of formula IA
- or a pharmaceutically acceptable salt thereof;
- wherein R1 is hydrogen or (C1-C3)alkyl optionally substituted with from one to five fluorine atoms;
- R2 is hydrogen or (C1-C3)alkyl optionally substituted with from one to five fluorine atoms;
- and
- R3 is (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl-(C1-C3)alkyl, phenyl, phenyl-(C1-C3)alkyl, or phenyl-N(H)—, wherein each alkyl is optionally substituted with from one to five fluorine atoms, and each phenyl is optionally substituted with from one to three substituents independently selected from chloro, fluoro, amino, nitro, cyano, (C1-C3)alkylamino, (C1-C3)alkyl optionally substituted with from one to three fluorine atoms, and (C1-C3)alkoxy optionally substituted with from one to three fluorine atoms;
- with the proviso that when R1 is hydrogen, R2 is not hydrogen.
3 more elements
(canceled)
(canceled)
7-13. (canceled)
Dependencies are inferred from the claim text.