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US 2006/0154943 A1Published application
Benzofuran derivatives and their use in the treatment of microbial infections
AssigneeArpida AG
InventorsSorana Greiveldinger-Poenaru, Dieter Gillessen, Kaspar Burri
Life of this patent
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Abstract
The invention relates to new benzofuran derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.
Claims23
A compound of formula I
- wherein
- R1 represents the groups
- whereby in these groups R5 is hydrogen, lower alkyl with 1 to 4 carbon atoms, or the group
- wherein
- R8 represents, lower alkyloxy, lower alkylamino, or lower alkyl with 1 to 4 carbon atoms;
- R9 represents, lower alkyl with 1 to 4 carbon atoms;
- R8 and R9 together form a 5- or 6-membered heterocyclic ring containing one to two hetero atoms which can be the same or different and are oxygen or nitrogen;
- R6 represent hydrogen, halogen, nitro, or lower alkyloxy;
- R7 represents hydrogen;
- R2 and R3 independently represent hydrogen, lower alkyl with 1 to 3 carbon atoms, or together a lower alkylene group with 1 to 3 carbon atoms bridging the oxygen atoms and forming a five, six or seven membered ring;
- R4 represents hydrogen
- and pharmaceutically acceptable salts thereof.
9 more elements
A compound of formula I′
- wherein
- R1 represents the groups
- whereby in these groups R5 is hydrogen, lower alkyl with 1 to 4 carbon atoms, or the group
- wherein
- R8 represents, lower alkyloxy, or lower alkyl with 1 to 4 carbon atoms;
- R9 represents, lower alkyl with 1 to 4 carbon atoms;
- R8 and R9 together form a 5- or 6-membered heterocyclic ring containing one to two hetero atoms which can be the same or different and are oxygen or nitrogen;
- R6 represent hydrogen, halogen, nitro, or lower alkyloxy;
- R7 represents hydrogen;
- R2 and R3 independently represent hydrogen, lower alkyl with 1 to 3 carbon atoms, or together a lower alkylene group with 1 to 3 carbon atoms bridging the oxygen atoms and forming a five, six or seven membered ring;
- R4 represents hydrogen;
- and pharmaceutically acceptable salts thereof.
9 more elements
A compound of formula II
- wherein
- R2 and R3 represent methyl;
- R4 represents hydrogen;
- R5 and R6 are as defined in formula I;
- R7 represents hydrogen;
- and pharmaceutically acceptable salts thereof.
3 more elements
A compound of formula III
- wherein
- R2 and R3 represent methyl;
- R4 represents hydrogen;
- R5 and R6 are as defined in formula I;
- R7 represents hydrogen;
- and pharmaceutically acceptable salts thereof.
3 more elements
A compound of formula IV
- wherein
- R2 and R3 represent methyl;
- R4 represents hydrogen;
- R5 and R6 are as defined in formula I;
- R7 represents hydrogen;
- and pharmaceutically acceptable salts thereof.
3 more elements
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.