Condensed azepines as vasopressin agonists

A compound according to general formula 1, or a pharmaceutically acceptable salt thereof,

• wherein
• A is a bicyclic or tricyclic azepine derivative selected from general formulae 2 to 7
• A1, A4, A7 and A10 are each independently selected from CH2, O and NR8;
• A2, A3, A9, A11, A13, A14 and A15 are each independently selected from CH and N;
• either A5 is a covalent bond and A6 is S, or A5 is N═CH and A6 is a covalent bond;
• A8 and A12 are each independently selected from NH and S;
• A18 and A17 are both CH2, or one of A16 and A17 is CH2 and the other is selected from CH(OH), CF2, O, Sox, and NR8,
• V1 and V2 are both H, OMe or F, or one of V1 and V2 is OH, OMe, OBn, OPh, O-acyl, Br, CI, F, N3, NH2, NHBn or NH-acyl and the other is H, or V1 and V2 together are ═O, —S(CH2)pS— or —O(CH2)pO—;
• W1 is either O or S;
• X1 and X2 are both H, or together are ═O or ═S;
• Y is OR5 or NR6R7;
• Z is S or —CH═CH—;
• R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, CI and Br;
• R5 is slected from H and lower alkyl;
• R6 and R7 are independently selected from H and lower alkyl, or together are —(CH2)n-;
• R8 is H or lower alkyl;
• N=3, 4, 5 or 6;
• P=2 or 3;
• and x is 0, 1 or 2.