Phosphorylated dextrans
OwnerTadao Saito, Haruki Kitazawainventors
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Abstract
Dextrans, which have no immunoreactivity, were revealed to exert immunopotentiating activities on their chemical phosphorylation. Since phosphorylated dextrans not only function as B cell mitogens, but also activate dendritic cells and induce IL-10 and IFN-γ, they can be expected to have effects in preventing infectious diseases and colitis, and in preventing allergic diseases by maintaining the Th1/Th2 balance.
Claims16
An agent comprising a phosphorylated dextran as an active ingredient, and having an immunopotentiating activity.
A pharmaceutical composition for preventing, improving, or treating infectious diseases, colitis, or allergic diseases, wherein the composition comprises a phosphorylated dextran as an active ingredient.
A food composition for preventing or improving infectious diseases, colitis, or allergic diseases, wherein the composition comprises a phosphorylated dextran as an active ingredient.
A method for immunopotentiating a cell, which comprises the step of contacting the cell with a phosphorylated dextran.
A method for producing a phosphorylated dextran, which comprises the step of reacting a dextran with polyphosphoric acid in a formaldehyde solution.
Dependencies are inferred from the claim text.