Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis

The method of claim 9, wherein said virus is a retrovirus.

3-5. (canceled)

The method of claim 9, wherein said cells are in vitro.

The method of claim 9, wherein said animal cells are mammalian cells.

The method of claim 9 wherein said virus is the human immunodeficiency virus (HIV) and said cells are human cells.

A method for inhibiting replication of reverse transcriptase dependent virus in animal cells, comprising the step of administering to said cells a synergistic combination of hydroxyurea and a nucleoside phosphate analog other than a thymidine or cytidine analog.

10-11. (canceled)

A method for inhibiting replication of reverse transcriptase dependent viruses in animal cells, comprising the step of administering to said cells a synergistic combination of hydroxyurea and a nucleoside phosphate analog other than a thymidine or cytidine analog, wherein the hydroxyurea depletes the intracellular pool of deoxyribonucleoside phosphate and wherein the nucleoside phosphate analog serves to inhibit replication of said virus by terminating DNA chain elongation.

13-15. (canceled)

A method of producing incomplete viral DNA from a reverse transcriptase dependent virus in animal cells, comprising the step of administering to said cells a synergistic combination of hydroxyurea and a nucleoside phosphate analog other than a thymidine or cytidine analog, wherein the combination is administered in an amount effective to inhibit replication of said virus.