Regulatory elements in the 5' region of the VR1 gene
AssigneeGruenenthal GmbH
InventorsEberhard Weihe, Annette Bieller, Martin Schaefer
Life of this patent
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Abstract
A nucleic acid comprising a sequence section which modulates the expression of the VR1 receptor, a vector containing this nucleic acid and a host cell which is transformed with this vector are disclosed, along with related pharmaceutical formulations. Methods for modulating the expression of the VR1 receptor and the use of the nucleic acid or vector for alleviating, preventing or treating pain and for treating sensibility disorders associated with the VR1 receptor are also provided.
Claims30
A nucleic acid comprising a sequence section which contains at least one region which modulates the expression of the VR1 receptor, said sequence section having a sequence selected from the group consisting of:
- FIG. 3 (SEQ ID NO:
- 7);
- FIG. 4 (SEQ ID NO:
- 8);
- GenBank Accession Number AL670399, positions 221931 to 223344;
- GenBank Accession Number AL663116, positions 31673 to 36359;
- GenBank Accession Number AF168787, positions 44731 to 43231;
- and GenBank Accession Number AF168787, positions 36616 to 33151, or a homologous derivative, allele or fragment thereof which modulates the expression of the VR1 receptor, or a sequence which hybridizes with one of the foregoing under standard conditions.
Dependencies are inferred from the claim text.