Transcript factor and an Akt substrate related to transcriptional action of insulin and applications of same
AssigneeEmory University
InventorBetty Villafuerte
Life of this patent
Estimating the term…
Abstract
A transcription factor capable of activating multiple insulin-responsive genes. In one embodiment, the transcription factor includes an NH2-domain containing thirteen epidermal growth factor (EGF)-like repeats proximate to the N-terminus, a solitary calcium-binding EGF-like domain proximate to the C-terminus, and three consecutive fibronectin type III (fn3) domains between the NH2-domain and the EGF-like domain.
Claims26
A transcription factor capable of activating multiple insulin-responsive genes, comprising:
- a. an NH2-domain containing thirteen epidermal growth factor (EGF)-like repeats proximate to the N-terminus;
- b. a solitary calcium-binding EGF-like domain proximate to the C-terminus;
- and
- c. three consecutive fibronectin type III (fn3) domains between the NH2-domain and the EGF-like domain.
A method of regulating the expression of gene transcription by insulin, comprising the step of using a transcription factor for binding and transactivating the insulin-response elements of an insulin-like growth factor binding protein-3.
A method of regulating the expression of gene transcription by insulin, comprising the step of using sensitin for binding and transactivating the insulin-response elements of an insulin-like growth factor binding protein-3.
Dependencies are inferred from the claim text.