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US 2006/0154860 A1Published application
Manipulating stem-progenitor cell trafficking to injured tissue and/or tumors by altering HIF-1 and/or SDF-1 activity
OwnerDaniel Ceradini, Geoffrey Gurtnerinventors
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Abstract
The present invention relates to a method for modulating recruitment of stem cells or progenitor cells to a selected tissue site. Methods for treating damaged tissue and for treating cancerous tumor tissue are also disclosed. These methods involve regulating HIF-1 and/or SDF-1 activity in the tissue.
Claims30
A method of treating damaged tissue, said method comprising:
- increasing activity of hypoxia-inducible factor-1 and/or activity of stromal cell-derived factor-1 in damaged tissue to a level above that caused by damage alone to the tissue, under conditions effective to treat the damaged tissue.
The method according to claim 4, wherein the tissue is in a human patient.
A method of modulating recruitment of stem cells and/or progenitor cells to a selected tissue site, said method comprising:
- controlling activity of hypoxia-inducible factor-1 and/or activity of stromal cell-derived factor-1 at the selected tissue site to a level different than activity otherwise present at the selected tissue site, under conditions effective to modulate recruitment of stem cells and/or progenitor cells to the selected tissue site.
A method of treating cancer in a subject, said method comprising:
- limiting activity of hypoxia-inducible factor-1 and/or activity of stromal cell-derived factor-1 in cancerous tumor tissue in the subject under conditions effective to treat the subject's cancer.
Dependencies are inferred from the claim text.