Leptin antagonists
AssigneesYissum Research Development Company of the Hebrew University of Jerusalem, Universites Paris 6 et Paris 7, Institut Nationale de la Recherche Agronomique (INRA)
InventorsArieh Gertler, Isabelle Callebaut, Jean Djiane
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Abstract
The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonists.
Claims22
A synthetic leptin antagonist in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonist.
Dependencies are inferred from the claim text.