Prostate-specific antigen probes for optical imaging

A peptide substrate probe having the following formula (I):

• D-Gly-Hyp-Ala-Ser-Chg-Gln-Ser-Leu-Met-Lys(FITC)-Cys-P (I)
• wherein,
• D is one selected from the group consisting of Cy5.5, Cy5, Cy7 and Alexa 750, Alexa 660, Alexa 680, IR 800, a lanthanum series metal complex and a near-infrared fluorescence dye;
• P is one selected from the group consisting of a polysaccharide, a polylysine, a polyethylene imine and a synthetic polymer.

A method for diagnosing a human prostatic cancer comprising the steps of:

• (a) synthesizing a prostate peptide substrate and a control peptide;
• (b) synthesizing a prostate peptide substrate probe and a prostate control peptide probe;
• and
• (c) diagnosing the human prostatic cancer with the prostate peptide substrate probe and the prostate control peptide probe.