Extracellular serine protease
AssigneeBoard of Trustees of the University of Arkansas
InventorsLowell Underwood, Timothy O'Brien
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Abstract
The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
Claims18
A method of diagnosing cancer in an individual, comprising:
- detecting Tumor Antigen Derived Gene-14 (TADG-14) protein or TADG-14 mRNA in a biological sample of an individual, wherein the presence of TADG-14 protein or TADG-14 mRNA indicates the individual has a cancer.
A method of diagnosing cancer in an individual, comprising:
- contacting a biological sample of an individual with a labeled-antibody specific for TADG-14 protein;
- and
- determining if said labeled-antibody binds to a component of the biological sample via the detection of the label, wherein the presence of bound labeled antibody is indicative of the presence of a cancer in the individual.
A method of diagnosing cancer in an individual, comprising:
- obtaining a cell sample from an individual;
- contacting mRNA obtained from the cell sample with a labeled hybridization probe having a sequence complementary to a DNA encoding TADG-14 protein or a fragment of said DNA;
- and
- determining if said labeled hybridization probe hybridizes with the mRNA via detection of the label, wherein the hybridization of the labeled probe to the mRNA is indicative of the presence of a cancer in the individual.
Dependencies are inferred from the claim text.