Regulated genes in cervical cancer
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsGregory Sgarlato, Catharine Eastman, Howard Sussman
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Abstract
Polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in SCCC cells are provided. The polynucleotides find use in diagnosis of cancer, and classification of cancer cells according to expression profiles. The methods are useful for detecting cervical cancer cells, facilitating diagnosis of cervical cancer and the severity of the cancer (e.g., tumor grade, tumor burden, and the like) in a subject, facilitating a determination of the prognosis of a subject, and assessing the responsiveness of the subject to therapy.
Claims12
A method for the diagnosis or staging of cervical cancer, the method comprising:
- determining the upregulation of expression of a genetic sequence selected from those listed in Table 2, groups I and Group II, Table 5 and/or Table 6.
A method of imaging a cervical cancer, the method comprising:
- administering to a patient an effective amount of a compound that specifically binds a polypeptide encoded by a genetic sequence set forth in Table 2 and/or Table 5 wherein said compound is conjugated to an imaging moiety;
- and
- visualizing the imaging moiety of said conjugate.
A method of screening candidate agents for modulation of a cervical cancer target protein, the method comprising:
- combining a candidate biologically active agent with any one of:
- (a) a polypeptide encoded by encoded by a genetic sequence set forth in Table 2, groups I and Group II, Table 5 and/or Table 6;
- (b) a cell comprising a nucleic acid encoding and expressing a polypeptide encoded by encoded by a genetic sequence set forth in Table 2, groups I and Group II, Table 5 and/or Table 6;
- and
- determining the effect of said agent on activity of the polypeptide, wherein agents that modulate said polypeptide activity provide a candidate therapeutic agent for cervical cancer.
Dependencies are inferred from the claim text.