Prevention of flap necrosis in plastic surgery
OwnerJonathan Stamler, Michael Zenn +1inventors
InventorsJonathan Stamler, Michael Zenn, Eric Toone
Life of this patent
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Abstract
NO, NO donor or prodrug that causes formation of nitrosothiol in tissue optionally in combination with lidocaine is topically applied to pedicle of a pedicle flap or other source of blood supply to prevent necrosis in pedicle flap or in any microvascular surgery. Composition containing drug is formulated with nitrosylated polythiolated cyclodextrin to improve drug delivery.
Claims8
A method for preventing necrosis in a pedicle flap or in any microvascular surgery comprising topically applying to pedicle or other source of blood supply, a therapeutically effective amount of vasodilator composition containing NO or NO donor or prodrug that causes formation of nitrosothiol in tissue, optionally in combination with lidocaine.
A method for delivering a drug comprising incorporating the drug in a gel or in a solution or in a pharmaceutical base, containing from 1 μM to 100 μM nitrosylated polythiolated cyclodextrin or other nitrosylated polymer or long lived gel coating equivalent exemplified by cyclodextrin or coating the drug in pill form with a coating that delivers nitric oxide, and administering the resulting drug containing composition topically to the skin or topically to the gastrointestinal tract.
Dependencies are inferred from the claim text.