Nanoparticles of polypoxyethylenated derivatives
OwnerMaria Jose Fernandez, Alejandro Barreiro +1inventors
InventorsMaria Jose Fernandez, Alejandro Barreiro, Noemi Csaba
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Abstract
The invention relates to nanoparticles of polyoxyethylenated derivatives, having a size of less than 1 micrometer, for the administration of pharmaceutically- or cosmetically-active ingredients. The inventive nanoparticles comprise a biodegradable polymer, a polyoxyethylene-derived block copolymer and at least one pharmaceutically- or cosmetically-active ingredient. The invention further relates to the method of obtaining the aforementioned nanoparticles and to compositions containing same.
Claims17
A method of preparing nanoparticles, having a size of less than 1 μm, for the administration of active ingredients, comprising the steps of:
- a) dissolving a biodegradable polymer together with a polyoxyethylene-derived block copolymer in an organic solvent, the weight ratio of both polymers being between 1:0.1 and 1:3;
- b) adding, with stirring, the solution obtained to a polar phase, wherein the biodegradable polymer has low solubility, precipitating the polymer and forming the nanoparticles;
- c) eliminating the organic solvent;
- and
- d) isolating the particles,
- wherein the active ingredient is dissolved in the organic solvent used in a) before or after step a), or is dissolved in a small volume of the aqueous phase, which is then dispersed in the organic solvent used in a), before or after step a).
Dependencies are inferred from the claim text.