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OwnerBen Adler, Paul Cullen +3inventors
InventorsBen Adler, Paul Cullen, Scott Coutts, Dieter Bulach, Ruud Phillip Segers
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The present invention relates to nucleic acid sequences encoding a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such lipoproteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, lipoproteins or immunogenic parts thereof and antibodies against such lipoproteins or immunogenic parts thereof. Also, the invention relates to the use of said lipoproteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, lipoproteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, lipoprotein or antibodies against such lipoprotein.
1-4. (canceled)
A DNA fragment comprising a nucleic acid sequence according to claim 25.
A recombinant DNA molecule comprising a nucleic acid sequence according to claim 25, under the control of a functionally linked promoter.
A live recombinant carrier comprising a nucleic acid sequence according to claim 25.
A host cell comprising a nucleic acid sequence according to claim 25.
9-18. (canceled)
A vaccine for combating Brachyspira hyodysenteriae infection comprising antibodies against a lipoprotein according to claim 29, and a pharmaceutically acceptable carrier.
(canceled)
A diagnostic kit for detecting Brachyspira hyodysenteriae or antibodies thereto, comprising a nucleic acid sequence according to claim 25, or a lipoprotein or antigenic fragment thereof encoded by said sequence, or antibodies that are reactive with said lipoprotein.
A nucleic acid sequence encoding an immunogenic 61 kD Brachyspira hyodysenteriae lipoprotein, as measured by SDS-PAGE.
A nucleic acid sequence encoding an immunogenic 20 kD Brachyspira hyodysenteriae lipoprotein, as measured by SDS-PAGE.
An isolated immunogenic Brachyspira hyodysenteriae lipoprotein of 61 kD, as measured by SDS-PAGE.
An isolated immunogenic Brachyspira hyodysenteriae lipoprotein of 20 kD, as measured by SDS-PAGE.
Dependencies are inferred from the claim text.