Use of protein histidine phosphatase
AssigneeMerck Patent GmbH
InventorsRoland Kellner, Susanne Klumpp
Life of this patent
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Abstract
The invention relates to the use of polypeptides with protein histidine phosphatase activity derived from mammalians, antibodies directed against them and DNA or RNA sequences complementary to mRNA sequences encoding polypeptides with protein histidine phosphatase activity for the modulation of ATP-citrate lyase and treatment of correlated pathophysiologic functions.
Claims9
Use of a polypeptide having the biological activity of a Protein Histidine Phosphatase (PHP) which has a high specificity for phosphohistidine or a homologue variant for the modulation of ATP-citrate-lyase (EC 4.1.3.8) activity.
A DNA sequence complementary to the mRNA sequence of protein histidine phosphatase having at least one of the following sequences
- I)
- TACCGCCACC GCCTGGAGCG AGAGTAAGGA CTACACCTGT
- AGCTGAGGCT GCCGCAGAAG TTCATACACG ACTAGGCTCA
- GGTGAGCCGA GGGGCGAGGC CCCGAGGCCG ACGTCTCTCG
- TTCCTCTAGC ACGCGCCGAT GTTCACCCGA CTCATGGTAC
- GCCTGTAGAT GCTGTTTCAC AGCCCGCTGT ACGTGTTCGT
- TCCGACGCTG ACACTCACAG ACCCGCCGCC CGCGTAGAGG
- GTGGTCTCAG
- TCCTGTTCTT CTAAGTGCAC ATGCCGATAA GGTACCGGAT
- ACCAGGACGG GTCGTGCGGT AAAGTTGACT CTTTTAGTTTC
- GGTTCATGGG GCTGATGCTC CAGTGGACCC GATTGCTGCC
- GATG
- II)
- CTGACACTCA CAGACCCGCC GCCCGCGTAG AGGGTGGTCT
- CAGTCCTG
- Ill)
- CTGACACTCA CAGACCCGCC GCCCGCGTAG AGGGTGGTCT
- CAGTCCTGTT CTTCTAAGTG CACATGCCGA TAAGGTACCG
- GATACCAGGA CGGGTCGTG
- IV)
- ATGGTACGCC TGTAGATGCT GTTTCACAGC CCGCTGTACG
- TCTTCGTTCC GACGCTGACA CTCACAGACC CGCCGCCCGC
- GTAGAGGGTG GTCTCAGTCC TGTTCTTCTA AGTGCACATG
- CCGATAAGGT AC
Dependencies are inferred from the claim text.