Induction of tumor and viral immunity using antigen presenting cell co-culture products and fusion products
AssigneeUniversity of Pittsburgh
InventorsLouis Falo, Christina Celluzzi
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Abstract
Formulations comprising combinations of APCs and tumor cells and APCs and virally infected cells are disclosed. These formulations generally comprise hybridoma of at least one antigen presenting cell fused to either at least one tumor cell or at least one virally infected cell, or the products of co-cultures of antigen presenting cells and either tumor cells or virally infected cells. Methods for using these formulations in prophylactically and therapeutically treating patients are also disclosed.
Claims20
1-12. (canceled)
A formulation comprising the products of co-cultures of a plurality of first cells and a plurality of second cells;
- wherein said first cells are antigen presenting cells selected from the group consisting of macrophages, B-cells and dendritic cells, and said second cells are selected from the group consisting of tumor cells and virally infected cells.
A pharmaceutical composition comprising:
- the products of co-cultures of a plurality of first cells and a plurality of second cells;
- and
- a suitable pharmaceutical carrier;
- wherein said first cells are antigen presenting cells selected from the group consisting of macrophages, B-cells and dendritic cells, and said second cells are selected from the group consisting of tumor cells and virally infected cells.
25-30. (canceled)
A method for treating a patient comprising:
- administering to said patient an effective amount of a formulation comprising the products of co-culture of a plurality of first cells and a plurality of second cells;
- wherein said first cells are antigen presenting cells selected from the group consisting of macrophages, B-cells and dendritic cells, and said second cells are selected from the group consisting of tumor cells and virally infected cells;
- and
- wherein said administration results in stimulation of a CTL response.
Dependencies are inferred from the claim text.