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US 2006/0148761 A1Published application
Lipids
AssigneeCelltech R&D Limited
InventorsMichael Eaton, Timothy Norman, David Parker, Terence Baker, Andrew Weir, Catherine Catterall
Life of this patent
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Abstract
Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.
Claims35
A bipolar lipid comprising a cationic head (1) a hydrophobic backbone (2) and a hydrophilic tail (3) in which:
- (A) the cationic head comprises two or more cationic centres, each centre being covalently linked to one or more others by one or more carbon containing spacer groups;
- (B) the hydrophobic backbone comprises one or more hydrocarbon chains;
- and
- (C) the hydrophilic tail comprises one or more hydrophilic hydrocarbons each containing two or more atoms or groups capable of being solvated by water;
- each of said components (1) to (3) being covalently linked head (1) to backbone (2) to tail (3) and arranged such that at least one hydrocarbon chain in the hydrophobic backbone (2) is covalently linked to a carbon atom of a spacer group in the cationic head (1) and each hydrophilic hydrocarbon in the hydrophilic tail (3) is covalently linked to a chain in the backbone (2) to achieve at least a ten atom spacing along the chain between the tail (3) and the head (1).
2 more elements
25-28. (canceled)
34-35. (canceled)
38-45. (canceled)
Dependencies are inferred from the claim text.