Method of detecting bone paget's disease
OwnerHisashi Narimatsu, Takashi Sato +1inventors
InventorsHisashi Narimatsu, Takashi Sato, Masanori Gotoh
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Abstract
A method for detecting Paget disease of bone and an animal showing the pathology of Paget disease of bone are provided. In particular, there are provided associating Paget disease of bone with the mutation a chondroitin/chondroitin synthase gene comprising the amino acid sequence depicted in any one of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 66, SEQ ID NO: 68 or SEQ ID NO: 70 or the amount of expression of said gene, detection of Paget disease of bone, and a knockout animal prepared by knocking out the chondroitin/chondroitin synthase gene.
Claims5
A method for detecting Paget disease of bone by associating Paget disease of bone with the mutation of a gene coding a chondroitin synthase gene or the amount of expression of said gene.
A knockout animal wherein a glycosyltransferase gene comprising the amino acid sequence depicted in any one of SEQ ID NO:
- 2, SEQ ID NO:
- 4, SEQ ID NO:
- 6, SEQ ID NO:
- 66, SEQ ID NO:
- 68 or SEQ ID NO:
- 70 or any one of the amino acid sequences homologous thereto is partly or completely suppressed in expression.
Dependencies are inferred from the claim text.