US 2006/0135597 A1 · Large conductance calcium-activated k channel opener

Abstract

There are disclosed a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein ring A is a 5-membered heterocyclic ring containing any one of O, N or S, which ring may be substituted by R4, R1 is aryl, heterocyclic or heterocycle-substituted carbonyl; R2 is hydrogen, halogen, carboxy, amino, alkyl, alkoxycarbonyl, alkenyl or cycloalkyl; R3 is aryl, heterocyclic or alkyl; and R4 is hydrogen or alkyl, each of substituents may be substituted, or a pharmaceutically acceptable salt thereof as an active ingredient.

Claims25

Dependent claims

A large conductance calcium-activated K channel opener comprising a 5-membered heterocyclic compound of the formula (I):

wherein ring A is a ring represented by any one of the formulae:
R1 is a substituted or unsubstituted aryl, a substituted or unsubstituted heterocycle or a substituted or unsubstituted heterocycle-substituted carbonyl;
R2 is hydrogen, a halogen, carboxy, a substituted or unsubstituted amino, a substituted or unsubstituted alkyl, an alkoxycarbonyl, a substituted or unsubstituted alkenyl or a cycloalkyl;
R3 is a substituted or unsubstituted aryl, a substituted or unsubstituted heterocycle or a substituted or unsubstituted alkyl;
and
R4 is hydrogen or a substituted or unsubstituted alkyl;
or a pharmaceutically acceptable salt thereof as an active ingredient.

4 more elements

A 5-membered heterocyclic compound of the formula (II):

wherein ring A is a ring represented by any one of the formulae:
R1 is a substituted or unsubstituted aryl, a substituted or unsubstituted heterocycle or a substituted or unsubstituted heterocycle-substituted carbonyl;
R2 is a substituted alkyl;
R3 is a substituted or unsubstituted aryl, a substituted or unsubstituted heterocycle or a substituted or unsubstituted alkyl;
and
R4 is hydrogen or a substituted or unsubstituted alkyl;
provided that when R1 and R3 are phenyl, R2 is not carboxymethyl or ethoxycarbonylmethyl, or a pharmaceutically acceptable salt thereof.

4 more elements

A 5-membered heterocyclic compound of the formula (III):

wherein ring A is a ring represented by any one of the formulae:
R1 is a substituted or unsubstituted thienyl, or an aryl substituted by two halogens;
R2 is substituted alkyl;
R3 is a substituted or unsubstituted aryl, a substituted or unsubstituted heterocycle or a substituted or unsubstituted alkyl;
and
R4 is hydrogen or a substituted or unsubstituted alkyl;
provided that when R1 is 2-thienyl, R3 is not 2-thienyl;
or a pharmaceutically acceptable salt thereof.

5 more elements

Dependencies are inferred from the claim text.

Large conductance calcium-activated k channel opener

Life of this patent

Large conductance calcium-activated k channel opener

Life of this patent

Abstract

Claims25