3-(Carbonyl) 1h-indazole compounds as cyclin dependent kinases (cdk) inhibitors

A compound of the formula (I):

• or a salt, solvate or N-oxide thereof, wherein
• E is O, S or NH;
• G is selected from hydrogen;
• carbocyclic and heterocyclic groups having from 3 to 12 ring members;
• and acyclic C1-8 hydrocarbyl groups optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono- or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the acyclic C1-8 hydrocarbyl group may optionally be replaced by O, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1;
• provided that E—G is not OH or SH and further provided that E—G does not contain the group O—O;
• two adjacent moieties selected from R3, R4, R5 and R6, together with the carbon atoms to which they are attached, form a fused heterocyclic group having from 5 to 7 ring members and 1, 2 or 3 ring heteroatoms selected from N, O and S;
• and the other two moieties selected from R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members;
• a group Ra—Rb wherein Ra is a bond, O, CO, X1C(X2), C(X2)X1, X1C(X2)X1, S, SO, SO2, NRc, SO2NRcor NRcSO2;
• and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1.8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono- or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by O, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1;
• Rc is hydrogen or C1-4 hydrocarbyl;
• and
• X1 is O, S or NRc and X2 is ═O, ═S or ═NRc.