Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists

A tetrahydro-naphthalene derivative of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof:

• wherein
• n represents an integer of 0 to 6;
• R1 represents hydrogen or C1-6 alkyl;
• R2 and R3 together with the nitrogen atom to which they are attached, form a 3-8 membered saturated heterocyclic ring optionally interrupted by one or two atoms selected from the group consisting of oxygen, sulfur and nitrogen,
• wherein
• said saturated heterocyclic ring has one or more substituents selected from the group consisting of halogen, benzyl, hydroxy, carboxy, amino, oxo, aminocarbonyl, C1-6 alkoxycarbonyl, and C1-6 alkyl optionally substituted by hydroxy, carboxy, C1-6 alkoxy, or C1-6 alkoxycarbonyl,
• or
• R2 represents C2-6 alkenyl, C2-6 alkynyl, or C1-6 alkyl substituted by amino, hydroxy, C1-6 alkylamino, or di(C1-6 alkyl)amino;
• R3 represents hydrogen, C2-6 alkenyl, C2-6 alkynyl, or C1-6 alkyl optionally substituted by amino, hydroxy, C1-6 alkylamino, or di(C1-6 alkyl)amino;
• and
• R4 represents hydrogen halogen, C1-6 alkylthio, C1-6 alkyl optionally substituted by mono-, di-, or tri-halogen, or C1-6 alkoxy optionally substituted by mono-, di-, or tri-halogen.