Phosphono-carboxylate compounds for treating amyloidosis
OwnerWalter Szarek, Xianqi Kong +2inventors
InventorsWalter Szarek, Xianqi Kong, Gregory Thatcher, Boris Gorine
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Abstract
Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
Claims1
A method for modulating amyloid deposition in a subject, comprising administering to a subject an effective amount of a therapeutic compound such that modulation of amyloid deposition occurs, wherein the therapeutic compound has the formula:
- in which
- R1 and R2 are each independently hydrogen, a substituted or unsubstituted aliphatic group, an aryl group, a heterocyclic group, or a salt-forming cation;
- R3 is hydrogen, lower alkyl, aryl, or a salt-forming cation;
- R4 is hydrogen, lower alkyl, aryl or amino;
- X is, independently for each occurrence, O or S;
- Y1 and Y2 are each independently hydrogen, halogen, alkyl, amino, hydroxy, alkoxy, or aryloxy;
- Z is XR2 or R4;
- and
- n is an integer from 0 to 12.
Dependencies are inferred from the claim text.