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AssigneeMcNeil-PPC, Inc.
InventorsMark Tawa, Julius Remenar, Matthew Peterson, Orn Almarsson, Hector Guzman, Hongming Chen, Mark Oliveira
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The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
1-45. (canceled)
A pharmaceutical composition comprising:
A process for producing a pharmaceutical composition for delivering a supersaturated concentration of a drug having an aqueous solubility less than about 10 mg/mL in gastric fluid conditions, which process comprises intimately mixing together components:
Dependencies are inferred from the claim text.