Comparative genomic hybridization significance analysis using data smoothing with shaped response functions
OwnerNicholas Sampas, Bo Curryinventors
Life of this patent
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Abstract
Methods and systems for analyzing comparative genomic hybridization data. The methods comprise measuring comparative genomic hybridization data, and applying a shaped response function to the comparative genomic hybridization data, wherein the shaped response function has a central maximum. The comparative genomic hybridization data may be obtained from a comparative genomic hybridization array. The shaped response function in many embodiments is symmetrical in shape tapers to zero on each side of said central maximum.
Claims23
A method for smoothing comparative genomic hybridization data, comprising:
- (a) measuring comparative genomic hybridization data;
- and
- (b) applying a shaped response function to said comparative genomic hybridization data, said shaped response function having a central maximum.
A method for analysis of comparative genomic hybridization array data, comprising:
- (a) measuring comparative genomic hybridization array data;
- and
- (b) applying a shaped response function to said comparative genomic hybridization array data, said shaped response function having a central maximum, said shaped response function symmetrically tapering to zero on each side of said central maximum.
A comparative genomic hybridization array data analysis system, comprising:
- (a) means for applying a shaped response function to comparative genomic hybridization array data, said shaped response function having a central maximum, said shaped response function symmetrically tapering to zero on each side of said central maximum;
- (b) means for determining significance levels for smoothed data obtained from applying said shaped response function to said comparative genomic hybridization array data;
- and
- (c) means for generating a graphical representation of said smoothed data.
In a computer readable medium, stored programming comprising:
- (a) means for applying a shaped response function to comparative genomic hybridization array data, said shaped response function having a central maximum, said shaped response function symmetrically tapering to zero on each side of said central maximum;
- (b) means for determining significance levels for smoothed data obtained from applying said shaped response function to said comparative genomic hybridization array data;
- and
- (c) means for generating a graphical representation of said smoothed data.
Dependencies are inferred from the claim text.