Renal infusion systems and methods

A system for delivering treatment to the renal arteries, the system comprising:

• a delivery catheter having a distal bifurcation;
• an introducer assembly comprising an introducer sheath in operative association with a Y-hub, wherein the introducer sheath has a length in the range from about 5 cm to about 25 cm, and the Y-hub includes a first port for receiving the delivery catheter and a second port for receiving a second catheter;
• and
• a constraint assembly for holding the distal bifurcation of the delivery catheter in a low-profile configuration when it is advanced distally beyond the introducer sheath.

A method of positioning a delivery catheter in a branch lumen extending from a main lumen in a body of a patient, the method comprising:

• positioning an introducer sheath in the main lumen;
• advancing a delivery catheter having a distal bifurcation through the introducer sheath;
• constraining the distal bifurcation in a low-profile configuration;
• advancing the constrained distal bifurcation from the introducer sheath toward the branch lumen;
• and
• releasing the distal bifurcation from the constrained low-profile configuration to allow entry of a first distal extension of the distal bifurcation into the branch lumen.