Process for the puritication of a salt of clavulanic acid
AssigneeSmithKline Beecham Corporation
InventorsJohn McKnight, Guo Zhang
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Abstract
A process in which a salt of clavulanic acid, typically an amine salt or an alkali metal salt is exposed to conditions, particularly a pH of less than 6.0, which reduces the quantity of contaminating impurities. The process may be a washing process, a recrystallisation process or a preparative process.
Claims32
A process comprising exposure of a salt of clavulanic acid to a liquid medium at a pH of less than 6.5.
A process according to claim 18 performed in a two phase system, being an organic solvent phase containing the clavulanic acid, and an aqueous phase into which the amine salt is extracted and which is at the pH of 6.0 or lower.
A process according to any one of the preceding claims, being part of an overall process for preparation of potassium clavulanate from crude clavulanic acid as formed in a fermentation broth.
A purification process in which a salt of clavulanic acid, containing or believed to be contaminated with N-succinyl tyrosine, is subjected to conditions which remove N-succinyl tyrosine.
A purification process in which a salt of clavulanic acid, containing or believed to be contaminated with N-succinyl tyrosine, is suspended or disssolved in a liquid medium and is exposed to a material which absorbs N-succinyl tyrosine and thereby removes N-succinyl tyrosine from the salt.
A preparative process in which a salt of clavulanic acid is prepared under conditions selected to minimise the formation of N-succinyl tyrosine and/or its retention in the product salt of clavulanic acid.
Dependencies are inferred from the claim text.