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US 2006/0079570 A1Published application
Alpha-aminoamide derivatives useful as antimigraine agents
AssigneeNewron Pharmaceuticals S.p.A.
InventorsPatricia Salvati, Marcello Calabresi, Luciano Dho, Orietta Veneroni, Piero Melloni
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Abstract
α-Aminoamide derivatives useful as antimigraine agents, particularly for the treatment of head pain conditions such as migraine, cluster headache or other severe headache, are disclosed. The antimigraine agents of the invention are able to reduce or even stop the pain deriving from such conditions without, virtually, any side effects.
Claims15
Use of an α-aminoamide of formula (I):
- wherein:
- A is a —(CH2)m— or —(CH2)n—X—, wherein m is 1 or 2;
- n is zero, 1 or 2;
- and X is —O—, —S— or —NH—;
- R is a furyl, thienyl, or pyridyl ring or a phenyl ring, unsubstituted or substituted by one or two substituents independently selected from halogen, hydroxy, C1-C4 alkyl,
- C1-C3 alkoxy and trifluoromethyl;
- R1 is hydrogen or C1-C3 alkyl;
- R2 is hydrogen or C1-C2 alkyl, unsubstituted or substituted by hydroxy or phenyl;
- phenyl, unsubstituted or substituted by one or two substituents independently selected from C1-C3 alkyl, halogen, hydroxy, C1-C2 alkoxy or trifluoromethyl;
- R3 is hydrogen or C1-C3 alkyl;
- if the case, either as a single isomer, or as a mixture thereof, or a pharmaceutically acceptable derivative thereof;
- in the manufacture of a medicament for the treatment of head pain conditions.
9 more elements
(canceled)
Dependencies are inferred from the claim text.