Anilino-pyrimidine analogs

A compound of formula I:

• wherein:
• R1 is hydrogen;
• R2 is selected from the group consisting of NR7R8, guanidinyl, ureido, optionally substituted imidazolyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, hydroxy, and alkoxy;
• R3 is selected from the group consisting of hydrogen;
• optionally substituted phenyl;
• an optionally substituted 5 or 6 membered heteroaryl ring with 1 to 4 heteroatoms, provided that the heteroaryl ring is not pyridine, furan, isoxazole, pyrazole, triazole, imidazole, or thiazole;
• a benzene ring fused to a 4 to 8 membered ring containing 0 to 4 heteroatoms, interrupted by 0 to 2 of the groups C═O, SO, or SO2, and optionally substituted;
• an optionally substituted monocyclic or polycylic ring containing 0 to 4 heteroatoms;
• optionally substituted alkenyl;
• optionally substituted alkynyl;
• —NR7R8;
• —COOR9;
• —CONR7R8;
• and —SO2R10;
• R4 is hydrogen;
• R5 is selected from the group consisting of hydrogen, methyl, alkyl, alkylcarbonyl, alkoxycarbonyl, alkylsulfonyl, hydroxymethyl, and alkylaminomethyl;
• R6 is selected from the group consisting of hydrogen;
• halogen;
• optionally substituted phenyl;
• an optionally substituted 5 or 6 membered heteroaryl ring with 1 to 4 heteroatoms;
• a benzene ring fused to a 4 to 8 membered ring containing 0 to 4 heteroatoms, interrupted by 0 to 2 of the groups C═O, SO, or SO2, and optionally substituted;
• an optionally substituted monocyclic or polycylic ring containing 0 to 4 heteroatoms;
• —NR7R8;
• —COOR9;
• —CONR7R8;
• —SO2R10;
• optionally substituted alkyl;
• optionally substituted alkenyl;
• optionally substituted alkynyl;
• hydroxy;
• alkoxy;
• OR7;
• and SR7;
• R7 and R8 are independently selected from the group consisting of hydrogen;
• optionally substituted alkyl;
• optionally substituted alkenyl;
• optionally substituted alkynyl;
• optionally substituted aryl;
• optionally substituted heteroaryl;
• hydroxy;
• alkoxy;
• alkylamino;
• arylamino;
• heteroarylamino;
• —NCOR9;
• —COR9;
• —CONR7R8;
• SO2R10;
• optionally substituted 3 to 10 membered cyclic amines containing 0 to 3 heteroatoms;
• optionally, R7 and R8 together form an optionally substituted 3 to 12 membered monocyclic or bicyclic ring containing 0 to 4 heteroatoms;
• R9 is selected from the group consisting of hydrogen, methyl, trifluoromethyl, optionally substituted alkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• R10 is selected from the group consisting of methyl, trifluoromethyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, and NR7R8;
• and the salts, solvates, and hydrates thereof.