IL-receptor like molecules and uses thereof
AssigneeAmgen Inc.
InventorsEugene Medlock, Richard Yeh, Scott Silbiger, Gary Elliott, Hung Nguyen, Shuqian Jing
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Abstract
The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
Claims13
1-89. (canceled)
A method for identifying a modulator of IL-17 receptor like polypeptide activity comprising:
- (a) exposing a cell to a test compound, wherein the cell is transformed or transfected with a polynucleotide sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:
- (1) an amino acid sequence that is at least 90 percent identical to amino acids 14 through 350 of SEQ ID NO:
- 5, wherein the polypeptide binds IL-17;
- (2) amino acids 1 through 560 of SEQ ID NO:
- 5;
- (3) amino acids 1 through 350 of SEQ ID NO:
- 5;
- (4) amino acids 14 through 350 of SEQ ID NO:
- 5;
- (5) the amino acid sequence encoded by the nucleotide sequence comprising nucleotides 50 through 1729 of SEQ ID NO:
- 4;
- (6) the amino acid sequence encoded by the nucleotide sequence comprising nucleotides 50 through 1099 of SEQ ID NO:
- 4;
- or
- (7) the amino acid sequence encoded by the nucleotide sequence comprising nucleotides 89 through 1099 of SEQ ID NO:
- 4;
- (b) detecting IL-17 receptor like polypeptide activity in said cell, and
- (c) comparing activity of IL-17 receptor like polypeptide in the presence and absence of the test compound, wherein an increase in IL-17 receptor like polypeptide activity indicates the candidate modulator is a stimulator of IL-17 receptor like polypeptide and wherein a decrease in IL-17 receptor like polypeptide activity indicates the test compound is an inhibitor of IL-17 like polypeptide activity.
A method of identifying a compound which binds to an IL-17 receptor like polypeptide comprising:
- (a) contacting the IL-17 receptor like polypeptide with a compound, wherein the polypeptide comprises an amino acid sequence selected from the group consisting of
- (1) an amino acid sequence that is at least 90 percent identical to amino acids 14 through 350 of SEQ ID NO:
- 5, wherein the polypeptide binds IL-17;
- (2) amino acids 1 through 560 of SEQ ID NO:
- 5;
- (3) amino acids 1 through 350 of SEQ ID NO:
- 5;
- (4) amino acids 14 through 350 of SEQ ID NO:
- 5;
- (5) the amino acid sequence encoded by the nucleotide sequence comprising nucleotides 50 through 1729 of SEQ ID NO:
- 4;
- (6) the amino acid sequence encoded by the nucleotide sequence comprising nucleotides 50 through 1099 of SEQ ID NO:
- 4;
- or
- (7) the amino acid sequence encoded by the nucleotide sequence comprising nucleotides 89 through 1099 of SEQ ID NO:
- 4;
- and
- (b) determining the extent of binding of the polypeptide to the compound.
A method for treating, preventing, or ameliorating a disease, condition, or disorder comprising administering to a patient an effective amount of an antagonist of IL-17 like polypeptide.
Dependencies are inferred from the claim text.