Biocompatible coatings for stents
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorSyed Hossainy
Life of this patent
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Abstract
A coating for a medical device, particularly for a stent, is described. The coating comprises a polymer and a biologically responsive compound. The coating can also contain a drug to provide enhanced therapeutic effect.
Claims19
A coating for an implantable medical device, comprising at least one polymer and at least one biologically responsive component physically blended with the polymer, wherein the biologically responsive component is selected from a group consisting of PLURONIC polyols, poly(vinyl pyrrolidone), hyaluronic acid, carboxymethylcellulose, poly(ethylene imine), poly(vinyl alcohol), polyacrylamide, sulfonated dextrane, silk-elastin block-copolymers, poly(ethylene oxide-co-ethylene imine), poly(ethylene oxide-co-vinyl pyrrolidone), poly(ethylene oxide-co-vinyl alcohol), poly(ethylene oxide-co-acrylamide), poly(ethylene oxide-co-sulfonated dextrane), PEG-hyaluronic acid adducts, adducts of silk-elastin block-copolymers with hyaluronic acid, sodium dodecyl sulfate, and blends thereof.
A method for inhibiting restenosis, the method comprising delivering a restenosis-inhibiting substance to a treatment site, the substance physically blended into a polymeric coating applied on a medical device, wherein the restenosis-inhibiting substance is selected from a group consisting of PLURONIC polyols, poly(vinyl pyrrolidone), hyaluronic acid, carboxymethylcellulose, poly(ethylene imine), poly(vinyl alcohol), polyacrylamide, sulfonated dextrane, silk-elastin block-copolymers, poly(ethylene oxide-co-ethylene imine), poly(ethylene oxide-co-vinyl pyrrolidone), poly(ethylene oxide-co-vinyl alcohol), poly(ethylene oxide-co-acrylamide), poly(ethylene oxide-co-sulfonated dextrane), PEG-hyaluronic acid adducts, adducts of silk-elastin block-copolymers with hyaluronic acid, sodium dodecyl sulfate, and blends thereof.
A method of coating a stent, comprising applying a physical blend of a polymer and a biologically responsive component to the stent, wherein the biologically responsive component is selected from a group consisting of PLURONIC polyols, poly(vinyl pyrrolidone), hyaluronic acid, carboxymethylcellulose, poly(ethylene imine), poly(vinyl alcohol), polyacrylamide, sulfonated dextrane, silk-elastin block-copolymers, poly(ethylene oxide-co-ethylene imine), poly(ethylene oxide-co-vinyl pyrrolidone), poly(ethylene oxide-co-vinyl alcohol), poly(ethylene oxide-co-acrylamide), poly(ethylene oxide-co-sulfonated dextrane), PEG-hyaluronic acid adducts, adducts of silk-elastin block-copolymers with hyaluronic acid, sodium dodecyl sulfate, and blends thereof.
Dependencies are inferred from the claim text.