Method of prevention and treatment of atherosclerosis, peripheral vascular disease, coronary artery disease, and age-related disorders including osteoporosis, arthritis, type 2 diabetes, dementia and Alzheimer's disease

A method of prevention and treatment of vascular and age-related disorders by inhibition or reduction of Interleukin-6 inflammation through regulation of cholesterol metabolism and isoprenoid depletion, in a human or other animal subject. Said method comprises administering, to said subject, in amounts which have the effect of ameliorating the vascular and age-related disorders, a HMG-CoA reductase inhibitor selected from the group including of lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rivastatin, red yeast rice, red yeast grain, red yeast powder and other statins or a pharmaceutically acceptable salt thereof.

A method of prevention and treatment of vascular and age-related disorders by inhibition or reduction of Interleukin-6 inflammation through regulation of cholesterol metabolism and isoprenoid depletion, in a human or other animal subject. Said method comprises administering, to said subject, in amounts which have the effect of ameliorating the vascular and age-related disorders, a bisphosphonate selected from the group including of Pamidronate, Etidronate, Clodronate, Alendronate, phosphonic acid derivatives, an ester thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof.

A method of prevention and treatment of vascular and age-related disorders by inhibition or reduction of Interleukin-6 inflammation through regulation of cholesterol metabolism and isoprenoid depletion, in a human or other animal subject. Said method comprises administering, to said subject, in amounts which have the effect of ameliorating the vascular and age-related disorders, a cholesterol lowering agent or technique selected from the group including of (i) low cholesterol or low fat diet (ii) sequestrants (cholestyramine, colestipol and dialkylaminoalkyl derivatives of a cross-linked dextran), (iii) nicotinyl alcohol, nicotinic acid or a salt thereof, (iv) PPAR.alpha. agonists such as fenofibric acid derivatives (gemfibrozil, clofibrate, fenofibrate and benzafibrate), (v) inhibitors of cholesterol absorption for example beta-sitosterol and (acyl CoA:cholesterol acyltransferase) inhibitors for example melinamide and (vi) probucol, an ester thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof.