US 2006/0069250 A1 · Synthesis by chiral diamine-mediated asymmetric alkylation

Abstract

Chiral synthesis from an achiral starting material by chiral diamine-mediated, such as sparteine-mediated, intermolecular asymmetric alkylation with a strained cyclic ether in the presence of a Lewis acid.

Claims47

Dependent claims

A method for making a chiral alkylated derivative of a nitrogen-containing heterocycle, comprising:

incorporating into a medium with an α-substitutable-N-heterocycle at least an organometalic compound, a chiral diamine, a strained cyclic ether, and a Lewis acid.

Dependencies are inferred from the claim text.

Facts

Application

11/237,185Filed 28 Sep 2005

Priority

30 Sep 2004

Published

30 Mar 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 401/06
Containing two hetero rings: linked by a carbon chain containing only aliphatic carbon atoms
C07D 203/10
With only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom: radicals substituted by…
C07D 203/18
With acylated ring nitrogen atoms: by carboxylic acids, or by sulfur or nitrogen analogues thereof
C07D 205/04
Not condensed with other rings: having no double bonds between ring members or between ring members and non-ring members

Abstract

Claims47

Dependent claims

A method for making a chiral alkylated derivative of a nitrogen-containing heterocycle, comprising:

incorporating into a medium with an α-substitutable-N-heterocycle at least an organometalic compound, a chiral diamine, a strained cyclic ether, and a Lewis acid.

Dependencies are inferred from the claim text.

Synthesis by chiral diamine-mediated asymmetric alkylation

Life of this patent

Abstract

Claims47

Synthesis by chiral diamine-mediated asymmetric alkylation

Life of this patent

Abstract

Claims47