Acylated aminopropanediols and analogues and therapeutic uses thereof
AssigneeGenfit
InventorsRaphael Darteil, Karine Caumont-Bertrand, Jamila Najib
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Abstract
The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method of preparing said derivatives.
Claims17
1-17. (canceled)
A compound represented by general formula (I)
- in which:
- G2 and G3 independently represent an oxygen atom, a sulfur atom or a N—R4 group, wherein G2 and G3 do not simultaneously represent a N—R4 group,
- R and R4 independently represent a hydrogen atom or a linear or branched alkyl group, saturated or not, optionally substituted, containing from 1 to 5 carbon atoms, R1, R2 and R3, which are the same or different, represent a hydrogen atom, a CO—R5 group or a group corresponding to the formula CO—(CH2)2n+1—X—R6, wherein at least one of the groups R1, R2 or R3 is a group corresponding to the formula CO—(CH2)2n+1—X—R6,
- R5 is a linear or branched alkyl group, saturated or not, optionally substituted, optionally comprising a cyclic group, the main chain of which contains from 1 to 25 carbon atoms,
- X is a sulfur atom, a selenium atom, a SO group or a SO2 group
- n is a whole number comprised between 0 and 11,
- R6 is a linear or branched alkyl group, saturated or not, optionally substituted, optionally comprising a cyclic group, the main chain of which contains from 3 to 23 carbon atoms, preferably 10 to 23 carbon atoms and possibly one or more heterogroups selected in the group consisting of an oxygen atom, a sulfur atom, a selenium atom, a SO group and a SO2 group,
- with the exception of a compound represented by formula (I) in which G2R2 and G3R3 simultaneously represent hydroxyl groups,
- the optical and geometrical isomer, racemate, salt, hydrate thereof and mixtures thereof.
A pharmaceutical composition comprising, in a pharmaceutically acceptable support, at least one compound represented by formula (I) such as defined in any of the previous claims, including a compound represented by formula (I) in which the groups G2R2 and G3R3 simultaneously represent hydroxyl groups.
Dependencies are inferred from the claim text.