Imidazolo-related compounds, compositions and methods for their use

A compound having the formula (I):

• or a pharmaceutically acceptable salt or prodrug thereof, wherein
• Q is a member selected from the group consisting of —C(O)—, —CH2CO—, —CH2SO— and —CH2SO2—;
• L is a bond or (C1-C5)alkylene;
• R0 is hydrogen, halogen, (C1-C8)alkyl, (C1-C8)heteroalkyl, fluoro(C1-C4)alkyl, aryl, heteroaryl, aryl(C1-C8)alkyl or heteroaryl(C1-C8)alkyl, or optionally, R0 groups on adjacent carbon atoms may be combined to form a 5- or 6-membered fused ring;
• the subscript n is 0, 1 or 2;
• R1 is heteroaryl or aryl;
• R2 is hydrogen, halogen, (C1-C10)alkyl, (C2-C10)heteroalkyl, hetero(C1-C10)cycloalkyl, (C1-C10)alkylaryl, or (C2-C10)heteroalkylaryl, or optionally R2 may be combined with L to form a 5-, 6-, 7- or 8-membered ring containing from 1 to 3 heteroatoms selected from the group consisting of N, O and S;
• R3 is absent or is a member selected from the group consisting of —H, —CHR6R7, —S(O)mR5, —S(O)mN(R8)R9, —S(O)mN(R8)CH2R6, —N(R8)SO2R5, —N(R8)CH2R10,
• wherein R5 is selected from the group consisting of (C1-C8)alkyl, (C2-C8)heteroalkyl, aryl and heteroaryl;
• R6 and R7independently are hydrogen, (C1-C8)alkyl or (C2-C8)heteroalkyl,
• R8 is hydrogen, (C1-C8)alkyl, (C2-C8)heteroalkyl, heteroaryl or aryl,
• R9 is (C1-C8)alkyl;
• R10 is aryl,
• Z is CH or N,
• X is a bond, (C1-C6)alkylene or (C1-C6)heteroalkylene,
• Y is (C1-C6)alkylene;
• the subscript m is 0, 1 or 2;
• and
• optionally, R3 may be combined with R2 to form a 4-, 5-, 6-, 7- or 8-membered ring containing from 1 to 3 heteroatoms selected from the group consisting of N, O and S;
• and
• R4 is a member selected from the group consisting of (C1-C20)alkyl, (C2-C20)heteroalkyl, heteroaryl, aryl, heteroaryl(C1-C6)alkyl, heteroaryl(C2-C6)heteroalkyl, aryl(C1-C6)alkyl and aryl(C2-C6)heteroalkyl.