US 2006/0069117 A1 · Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same

Abstract

Compounds of formula (I): wherein: R1 represents hydrogen, halogen, alkyl, polyhaloalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, R2 represents hydrogen, alkyl, an optionally substituted aryl, optionally substituted heteroaryl, or R20—C(X)— wherein: R20 represents alkyl, alkoxy, amino, alkylamino, dialkylamino, optionally substituted aryl or optionally substituted heteroaryl, X represents oxygen, sulphur, or NR21 wherein R21 represents hydrogen or alkyl, R3 represents hydrogen atom or alkyl, n represents integer from 1 to 6 inclusive, the representation its enantiomers, diastereoisomers and also addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as AMPK activators.

Claims16

Dependent claims

1-15. (canceled)

16- A compound of formula (I):

wherein:
R1 represents hydrogen, halogen, alkyl, polyhaloalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl,
R2 represents hydrogen, alkyl, optionally substituted aryl, optionally substituted heteroaryl, or R20—C(X)— wherein:
R20 represents alkyl, alkoxy, amino, alkylamino, dialkylamino, optionally substituted aryl or optionally substituted heteroaryl,
X represents oxygen, sulphur, or NR21 wherein R21 represents hydrogen or alkyl,
R3 represents hydrogen or alkyl,
n represents an integer from 1 to 6 inclusive,
the representation
its enantiomers, diastereoisomers and addition salts thereof with a pharmaceutically acceptable acid or base,
it being understood that:
the term “alkyl” denotes linear or branched hydrocarbon chain having from 1 to 6 carbon atoms,
the term “alkoxy” denotes an alkyl-oxy in which the alkyl chain, which is linear or branched, has from 1 to 6 carbon atoms,
the term “aryl” denotes phenyl or biphenyl,
the term “polyhaloalkyl” denotes a linear or branched carbon chain having from 1 to 3 carbon atoms and from 1 to 7 halogen atoms,
the term “heteroaryl” denotes a group having from 5 to 11 ring members which is monocyclic or bicyclic, in which at least one of the rings is aromatic, and which contains in the monocyclic ring system or in the bicyclic ring system 1, 2 or 3 hetero atoms selected from nitrogen, oxygen and sulphur, and
the expression “optionally substituted” associated with the expressions aryl and heteroaryl means that the groups in question are substituted by one or two identical or different substituents selected from halogen, alkyl, alkoxy, polyhaloalkyl, hydroxy, cyano, nitro, amino (optionally substituted by one or two alkyl groups) and —C(O)Rd wherein Rd represents a group selected from hydroxy, alkoxy and amino, it being understood that the heteroaryl may also be substituted by an oxo moiety on the non-aromatic moiety of the heteroaryl.

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Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same

Life of this patent

Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same

Life of this patent

Abstract

Claims16