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US 2006/0069016 A1Published application
Cyclosporin alkyne analogues and their pharmaceutical uses
AssigneeAMR Technology, Inc.
InventorsBruce Molino, Zhicai Yang
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Abstract
The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein.
Claims14
A compound of Formula I:
- wherein:
- X is OH or OAc;
- R0 is H, CH2OH, or CH2OR3;
- R1 is hydrogen, deuterium, or methyl;
- R2 is selected from the group consisting of:
- hydrogen;
- halogen;
- C1-C6 saturated or unsaturated, straight or branched carbon chain;
- C1-C6 saturated or unsaturated, straight or branched carbon chain containing a substitution or substitutions selected from the group consisting of deuterium, halogen, nitrogen, sulfur, and silicon;
- C1-C6 saturated or unsaturated, straight or branched carbon chain containing a function group or function groups selected from the group consisting of alcohol, ether, aldehyde, ketone, carboxylic acid, ester, and amide;
- C1-C6 saturated or unsaturated, straight or branched carbon chain containing a function group of oxime or hydrazone;
- C1-C6 saturated or unsaturated, straight or branched carbon chain containing an aryl or a heteroaryl group;
- C3-C6 substituted and unsubstituted cycloalkyl;
- substituted and unsubstituted aryl;
- and
- substituted and unsubstituted heteroaryl;
- and
- R3 is selected from the group consisting of:
- alkanoyl,
- alkenoyl,
- alkynoyl,
- aryloyl,
- arylalkanoyl,
- alkylaminocarbonyl,
- arylaminocarbonyl,
- arylalkylaminocarbonyl,
- alkyloxycarbonyl,
- aryloxycarbonyl, and
- arylalkyloxycarbonyl,
- wherein the compound is a cis geometric isomer, a trans geometric isomer, or a mixture of the cis and the trans geometric isomers or a pharmaceutically acceptable salt thereof.
27 more elements
Dependencies are inferred from the claim text.