Novel G protein-coupled receptor
AssigneeNational Research Council of Canada
InventorsSultan Ahmad, Denis Banville, Yves Fortin, Paola Lembo, Dajan O'Donnell, Shi-Hsiang Shen
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Abstract
The present invention is directed to novel G protein-coupled receptors that are found predominantly in the dorsal root ganglia. The invention encompasses both the receptor proteins as well as nucleic acids encoding the proteins. In addition, the present invention is directed to methods and compositions which utilize the receptors.
Claims42
A protein, except as existing in nature, comprising the amino acid sequence consisting functionally of rat dorsal root receptor 1 (DRR-1) as shown in SEQ ID NO:1.
A substantially pure polynucleotide encoding a protein comprising the amino acid sequence consisting functionally of rat DRR-1 as shown in SEQ ID NO:1.
A protein, except as existing in nature, comprising the amino acid sequence consisting functionally of human dorsal root receptor 1 (DRR-1) as shown in SEQ ID NO:3.
A substantially pure polynucleotide encoding a protein comprising the amino acid sequence consisting functionally of human DRR-1 as shown in SEQ ID NO:3.
A protein, except as existing in nature, comprising the amino acid sequence consisting functionally of human dorsal root receptor 2 (DRR-2) as shown in SEQ ID NO:5.
A substantially pure polynucleotide encoding a protein comprising the amino acid sequence consisting functionally of human DRR-2 as shown in SEQ ID NO:5.
A protein, except as existing in nature, comprising the amino acid sequence consisting functionally of human dorsal root receptor 3 (DRR-3) as shown in SEQ ID NO:7.
A substantially pure polynucleotide encoding a protein comprising the amino acid sequence consisting functionally of human DRR-3 as shown in SEQ ID NO:7.
A protein, except as existing in nature, comprising the amino acid sequence consisting functionally of human dorsal root receptor 4 (DRR-4) as shown in SEQ ID NO:9.
A substantially pure polynucleotide encoding a protein comprising the amino acid sequence consisting functionally of human DRR-4 as shown in SEQ ID NO:9.
A protein, except as existing in nature, comprising the amino acid sequence consisting functionally of human dorsal root receptor 5 (DRR-5) as shown in SEQ ID NO:11.
A substantially pure polynucleotide encoding a protein comprising the amino acid sequence consisting functionally of human DRR-5 as shown in SEQ ID NO:11.
A protein, except as existing in nature, comprising the amino acid sequence consisting functionally of human dorsal root receptor 6 (DRR-6) as shown in SEQ ID NO:13.
A substantially pure polynucleotide encoding a protein comprising the amino acid sequence consisting functionally of human DRR-6 as shown in SEQ ID NO:13.
A method for assaying a test compound for its ability to bind or to activate a G protein-coupled dorsal root ganglia specific receptor (DRR), comprising:
- a) incubating a source containing DRR but substantially free of other G protein-coupled receptors, with
- i) a ligand known to bind to DRR;
- ii) said test compound;
- and
- b) determining the extent to which said ligand binding is displaced by said test compound.
Dependencies are inferred from the claim text.